Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1
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Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1
Background Of the 230,000 new cases of invasive breast cancer diagnosed annually, 70% express the estrogen receptor-a and may be treated with anti-estrogen therapies. While these drugs induce clinical benefit, over 50% will develop resistance. Recently, we have determined a key role of the unfolded protein response endoplasmic reticulum protein chaperone, glucose-regulated protein 78 (GRP78), i...
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ژورنال
عنوان ژورنال: Cancer & Metabolism
سال: 2014
ISSN: 2049-3002
DOI: 10.1186/2049-3002-2-s1-p16